Er... possibly. Most of combat is done with the hotkey bar, so if you had something with movement controls (you autoturn to face mobs) and at least 6 but up to 11 would be good (one to control attack) you'd be fine, assuming you're not the MA or pulling. You'd just use one hotkey for assisting the MA, which you'd have to program for every group but that's not that big of a deal.